Supplementary information

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date de publication20.11.2017
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Supplementary information
One-step synthesis of iron oxide polypyrrole nanoparticles encapsulating ketoprofen as model of hydrophobic drug
Mohamed F. Attia,a,b,c Nicolas Anton,a,b,* Ikram U. Khan,a,d,e Christophe A. Serra,d Nadia Messaddeq,f Anshuman Jakhmola,g Raffaele Vecchione,g Thierry Vandammea,b
a University of Strasbourg, Faculty of Pharmacy, 74 route du Rhin 67401 Illkirch Cedex, France

b CNRS UMR 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, University of Strasbourg, route du Rhin No. 74, F-67401 Illkirch Cedex, France

c National Research Center, P.O. 12622, Cairo, Egyp

d Institut Charles Sadron (ICS) – UPR 22 CNRS, Université de Strasbourg, Strasbourg, France

e Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan

f IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U964, CNRS UMR7104, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France

g Istituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci, 53 80125 Napoli, Italy

S1: Chemical interaction between polypyrrole polymer and the PEGylated surfactant (solutol HS 15) through intramolecular hydrogen bonding [hydroxyl group of surfactant and NH group of pyrrole ring and /or strong ionic forces that resulted from positive charge of the polymer with negative charge of carbonyl group of the solutol.

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S2: Absorption measurements at different concentration of surfactant. Illustrates decreasing of absorbance while increasing of the surfactant in the nanocomposites.


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